Apabila seseorang terangsang secara seksual, signal akan dihantar daripada otak kepada zakar melalui sistem saraf bagi menghasilkan ereksi.Senyawa dalam obat kuat pria tersebut dapat merelaksasi otot-otot, sehingga pembuluh darah arteri di penis melebar dan darah mengalir ke penis dengan mudah.Spedra bertindak dengan menghalang enzim PDE5 yang bias
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